Completion bonuses
Successfully complete the game to unlock the Separate Ways and Mercenaries-mini-games; the Professional difficulty setting; the Leon's Raccoon City Police Department costume, Ashley's pop star costume, and Ada's black costume; the Mathilda handgun and Infinite Rocket Launcher for purchase (for 1 million Pesetas), and the Tactical Vest (for 60,000 Pesetas); and an alternate title screen.
After completing the game for the first time, you can begin a new game. Start a new game, press [Start], and select "Load Game". Select the file that is marked "Clear". Once you choose that file, you will be taken to a menu where you can buy the Matilda Handgun or the Infinite Rocket Launcher. Once you start the game, all of your items from your previous game will be in your item box.
Successfully complete the Separate Ways mini-game to unlock Ashley's knight costume and Leon's gangster costume. Ashley's suit of armor is bullet and damage proof. She cannot get hurt by anything and it is so heavy she cannot be carried away. You do not have to worry about giving her First Aid Sprays, Herbs, or shooting Ganados trying to pick her up.
Control title screen
Press the [Right Analog-stick] to move the background. Press [R1] to zoom the view in or [L1] to zoom out.
Alternate ending sequence
Successfully complete Assignment Ada and watch the credits. They will be in gray scale. However, if you select "Yes" when asked "Watch the ending movie again?", it will be replayed in color in a smaller frame. If you watch it once more when prompted, it will play is full wide screen color. They will alternate each time you choose to replay the credits.
Mercenaries mini-game: Bonus characters
Achieve a four star rank in the following areas to unlock the corresponding character in the Mercenaries mini-game.
Ada Wong: Pueblo
Albert Wesker: Waterworld
Hunk: Island Commando Base
Jack Krauser: Castle
Note: To unlock Albert Wesker easily, play as Krauser. All your arrows will kill the Ganados soldiers in one hit. Also, use your mutated arm on the dual wielding chainsaw men for a one hit kill.
Mercenaries mini-game: Weapons
| Name | Firepower | Firing Speed | Reload Speed | Capacity |
| Leon | | | | |
| Blacktail | 2.7 | 0.40 | 1.47 | 21 |
| Riot Gun | 7.0 | 1.53 | 1.67 | 13 |
| | | | | |
| Ada | | | | |
| Punisher | 1.9 | 0.33 | 1.47 | 20 |
| TMP | 1.0 | 0.10 | 1.93 | 100 |
| Rifle (semi-auto) | 15.0 | 0.80 | 1.90 | 12 |
| | | | | |
| Krauser | | | | |
| Bow | - | - | - | - |
| | | | | |
| Hunk | | | | |
| Custom TMP | 1.0 | 0.10 | 1.17 | 100 |
| | | | | |
| Wesker | | | | |
| Handgun | 2.0 | 0.33 | 0.87 | 25 |
| Killer7 | 30.0 | 0.70 | 1.53 | 10 |
| Rifle (semi-auto) | 15.0 | 0.80 | 1.90 | 24 |